We are happy to announce that our paper “Brain Connectivity Gradients Alterations in Discordant Cerebrospinal Fluid Profile for Alzheimer’s Disease Biomarkers” has been published on Human Brain Mapping by Wiley. If you’re curious about why some people show tau-positive but amyloid-negative CSF profiles, this study tests whether brain connectivity can separate discordant A−T+ individuals from concordant A+T+ cases in ADNI3. Using functional/structural connectivity gradients, the authors find that functional (but not structural) connectivity—especially along a temporo-occipital/posterior axis—distinguishes A−T+ from A+T+ with good accuracy, suggesting tau elevation without amyloid may reflect a distinct functional trajectory with different links to cognition compared to the classic DMN-related pattern seen in A+T+.